Sirio Dupont

Sirio Dupont received a Master in Molecular Biology in 2000, and his PhD in Developmental Biology in 2004. During his postoc he identified new regulatory mechanisms in TGFbeta and BMP signal transduction, and characterized their role in frog and mouse embryos. In the last 15 years his group identified new mechanotransduction players, including the seminal identification of YAP/TAZ as mechano-regulated transcriptional regulators, the demonstration that force mechanostranduction is key for contact-inhibition of growth, and the finding that force mechanostranduction maintains liver organ homeostasis in mice. More recently, the group focused on metabolic traits regulated by the mechanical microenvironment. From 2023 he is a Full Professor at the Medical School of the University of Padua. He was awarded Clarivate Highly Cited Resercher in 2021 and 2022.