10:30 - 11:15        EVOLUTION SESSION: From Basic Science to Cancer Research

THE EMBO KEYNOTE LECTURE

Insights into cancer evolution, immune evasion and metastases: TRACERx at 10 years

Charles SWANTON, The Francis Crick Institute, UK

Sponsored by EMBO

11:15 - 12:45        EVOLUTION SESSION: From Basic Science to Cancer Research

35' - Dissecting the Most Natural Experiment Ever: Evolution and Immunity
Lluis QUINTANA-MURCI, Institut Pasteur, FR

20' - Unravelling the role of early dissemination in colorectal cancer
Julie PANNEQUIN, Institut de Génomique Fonctionnelle - CNRS, FR

35' - Harnessing the mechanisms of disseminated cancer cell dormancy to prevent and treat metastatic relapse
Julio AGUIRRE-GHISO, Albert Einstein College of Medicine, US

14:15 - 15:10        EVOLUTION SESSION: From Basic Science to Cancer Research

35' - Families matters: the role of single cell families in hematopoiesis
Leila PERIE, Institut Curie, FR

20' - De novo evolution of human microproteins: driving forces and constraints
Nikolaos VAKIRLIS, BSRC Alexander Fleming, GR

15:10 - 16:05        IMMUNITY SESSION: From Basic Science to Cancer Research

35' - Ordering Chaos: Delineating The Cell-Intrinsic Metabolic Signals That Regulate Immune Cell Differentiation
Erika PEARCE, Johns Hopkins University, US

20' - Deciphering intratumoral heterogeneity in luminal breast cancer
Christina METOIKIDOU, Netherlands Cancer Institute, NL

16:35 - 18:05        IMMUNITY SESSION: From Basic Science to Cancer Research

20' - Intra-tumoral TREX1 induction promotes immune evasion by limiting type I interferon
Eleonore TOUFEKTCHAN, Memorial Sloan Kettering Cancer Center, US

35' - TE exonization in protein evolution 
Sebastian AMIGORENA, Institut Curie, FR

35' - Targetting myeloid cells in cancer
Miriam MERAD, Mount Sinai School of Medicine, US

18:05 - 18:50       IMMUNITY SESSION: From Basic Science to Cancer Research

KEYNOTE SPEAKER
Role of microbiota and nutrition in the control of host immunity
Yasmine BELKAID, Institut Pasteur, FR 

09:00 - 09:45        GENETICS SESSION: From Basic Science to Cancer Research

KEYNOTE SPEAKER
Cellular responses to DNA damage: mechanistic insights and medical applications
Steve JACKSON, CRUK Cambridge Institute, UK

09:45 - 11:00        GENETICS SESSION: From Basic Science to Cancer Research

35' - Genetic signatures and immunologic escape mechanisms in lymphoid malignancies
Margaret SHIPP, Dana Farber Cancer Institute, US

20' - Deamination of 5-hydroxymethylcytosine drives DNA damage
Hannah WEBB, MRC Laboratory of Molecular Biology, UK

20' - VC-Resist glioblastoma cell state: vessel co-option as a key driver of chemoradiation resistance
Giorgio SEANO, Institut Curie, FR

11:30 - 12:40        GENETICS SESSION: From Basic Science to Cancer Research

35 ' - Targeting the DNA Damage Response in the Clinic: Progress, Pitfalls and Promise
Timothy YAP, MD Anderson, US

35 ' - Maximising the potential of whole genome data to improve precision cancer medicine
Serena NIK-ZAINAL, University of Cambridge, UK

14:10 - 15:10        Round Table - Green in science

15:10 - 15:55        SYSTEMS SESSION: From Basic Science to Cancer Research

KEYNOTE SPEAKER
Physical principles for the “design” of genetic networks
William BIALEK, Princeton University, US

15:55 - 16:50        SYSTEMS SESSION: From Basic Science to Cancer Research

35' - Interactome networks and human disease
Marc VIDAL, Dana Farber Cancer Institute, US

20' - Modeling breast cancer initiation using organoids: kinetics and mechanisms
Marthe LAISNE, Institut Curie, FR

09:00 - 09:10        Opening Session

09:10 - 09:55        "SCIENCE HAS GREAT BEAUTY" by Marie Curie

KEYNOTE SPEAKER
Life with two X chromosomes
Edith HEARD, European Molecular Biology Laboratory, DE

Sponsored by Labex Deep

09:55 - 11:05        "SCIENCE HAS GREAT BEAUTY" by Marie Curie

35' - Genetic and Non-Genetic Mechanisms of Clonal Fitness
Mark DAWSON, Peter MacCallum Cancer Center, AU

35' - Conservation of anti-viral immunity across domains of life
Aude BERNHEIM, Institut Pasteur, FR

11:45 - 12:20       "SCIENCE HAS GREAT BEAUTY" by Marie Curie

Chemical Control of Cell-State Transitions
Raphaël RODRIGUEZ, Institut Curie, FR

12:20 - 13:05       "SCIENCE HAS GREAT BEAUTY" by Marie Curie

KEYNOTE SPEAKER
Control of the Cell Cycle
Paul NURSE, The Francis Crick Institute, UK